Approved February 2000
For lowering intraocular pressure (IOP) in patients with chronic open-angle glaucoma or ocular hypertension
Betaxon (levobetaxolol hydrochloride suspension, drops) is an ophthalmic suspension which, when instilled in the eye, reduces intraocular pressure (IOP), a major risk factor in glaucomatous field loss. Elevated IOP accounts for greater likelihood of optic nerve damage and visual field loss. Most of the diseases of the eye which cause glaucoma are characterized by increased IOP.
Currently, there is no cure for glaucoma. Furthermore, since there are no obvious symptoms, it is difficult to detect glaucoma before serious loss of sight is experienced. The best defense is to have regular eye exams. See below for a list of populations that are of higher risk for developing glaucoma.
In two clinical research studies in which a total of 365 patients were dosed for three months with the study drug, Betaxon was shown to significantly reduce IOP at all follow up visits.
The main adverse effects experienced by patients in clinical trials included:
In addition, the same adverse reactions that may occur with systemic beta-adrenergic blocking agents may result from this topically applied beta-adrenergic blocking agent. These effects may include:
Betaxon is contraindicated in patients with sinus bradycardia, greater than a first degree atrioventricular block, cardiogenic shock, or patients with over cardiac failure.
Results of clinical research indicate that this drug may have a minor effect on heart rate and blood pressure.
Since racemic betaxolol and other beta-adrenergic antagonists have been shown to reduce intraocular pressure by a reduction of aqueous production as demonstrated by tonography and aqueous flourophotometry, it is assumed that the mechanism of action of levobetaxolol is similar. The intraocular lowering effect of racemic betaxolol can generally be noted within 30 minutes and the maximal effect can usually be detected two hours after topical administration. It is assumed that the intraocular lowering time profile of levobetaxolol is similar. A single dose provides approximately a 12-hour reduction in intraocular pressure. (FDA Label)
According to the Glaucoma Foundation, you may be at greater risk for developing the glaucoma if:
The Betaxon drug information shown above is licensed from Thomson CenterWatch. The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.