Biaxin XL (clarithromycin extended-release tablets)Company: Abbott Laboratories
Approval Status: Approved March 2000
Treatment for: Acute Bacterial Exacerbation of Chronic Bronchitis (AECB) and Acute Maxillary Sinusitis
Areas: Immune System; Respiratory
Biaxin XL Tablets is an extended-release form of the antibiotic Biaxin (clarithromycin). Biaxin XL is indicated for the treatment of:
- Acute maxillary sinusitis (AMS) caused by
- Acute bacterial exacerbation of chronic bronchitis (AECB) caused by
[Biaxin Tablets (non extended-release) are also indicated for pharyngitis/tonsillitis, pneumonia, and uncomplicated skin and skin structure.]
Biaxin XL should be taken with food even though Biaxin Tablets and oral suspension may be taken with or without food.
94% of patients with Acute Exacerbation of Chronic Bronchitis (AECB) and 97% of patients with Acute Maxillary Sinusitis (AMS) taking Biaxin Tablets in clinical studies were cured or showed significant improvement.
The most common side effects are:
- Diarrhea (present in 6% of adults taking the medication)
- Abnormal taste (6%)
- Nausea (3%)
Discontinuation of treatment due to these adverse events occurred in fewer patients taking Biaxin XL than patients taking Biaxin Tablets.
Post-marketing spontaneously-reported adverse events included:
- Various allergic reactions
- Tooth discoloration
- Alterations of sense of smell (often occurs in conjunction with abnormal taste)
- Isolated reports of hearing loss (reversible)
- Various transient central nervous system events (often resolved by discontinuing use of drug)
- Infrequently reported hepatic dysfunction
- Rare cases of hypoglycemia
Biaxin XL is contraindicated in patients with allergies to clarithromycin, erythromycin, or any macrolide antibiotic.
Concomitant administration of Biaxin with cisapride, pimozide, or terfenadine is contraindicated. Fatalities due to interactions between clarithromycin and these drugs have been reported.
Clarithromycin should not be administered to pregnant women.
Biaxin XL Drug Information
The Biaxin Xl drug information shown above is licensed from Thomson CenterWatch. The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.