Lumigan (bimatoprost ophthalmic solution)
Company: Allergan
Approval Status: Approved March 2001
Treatment for: Glaucoma or ocular hypertension
Areas: Ophthalmology
| General Information | Clinical Results | Side Effects | Mechanism of Action | Additional Information |
General Information
Lumigan has been approved by the FDA for the reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension who are intolerant of or insufficiently responsive to other IOP-lowering medications. Bimatoprost, the active ingredient in Lumigan, is a synthetic prostamide analog - it acts by mimicking the effects of prostamides, which are naturally occurring substances. It is believed to lower intraocular pressure by increasing the outflow of fluid (known as aqueous humor) produced by the eye.
There are approximately two to three million individuals in the United States with glaucoma, a condition often associated with elevated intraocular pressure leading to optic nerve damage. Glaucoma is a leading cause of blindness for which there is currently no cure; however, recent opinion suggests that achieving a low level of IOP may slow the progression of the disease.
Clinical Results
Phase III trial results demonstrated that 64% of subjects receiving Lumigan once daily achieved target IOP of less than or equal to 17 mm Hg, whereas 37% of subjects receiving timolol twice daily, a leading drug used to lower IOP, achieved the same target pressure. At six months, Lumigan produced a 33% reduction in IOP compared to 23% with timolol (8.1 mm Hg vs. 5.6 mm Hg, respectively).
Side Effects
In clinical trials, adverse events occurring in approximately 15% to 45% of subjects included (but are not limited to) the following:
- Conjunctival hyperemia
- Growth of eyelashes
- Ocular pruritus
Events occurring in approximately 3 to 10% of subjects included those listed below:
- Ocular dryness
- Visual disturbance
- Ocular burning
- Foreign body sensation
- Eye pain
- Pigmentation of the periocular skin
- Eyelash darkening
Mechanism of Action
Bimatoprost is a prostamide, a synthetic structural analog of prostaglandin with ocular hypotensive activity. It selectively mimics the effects of naturally occurring substances called prostamides. Bimatoprost is believed to lower IOP in humans by increasing outflow of aqueous humor through both the trabecular meshwork and uveoscleral routes. Elevated IOP presents a major risk factor for glaucomatous field loss. The higher the level of IOP, the greater the likelihood of optic nerve damage and visual field loss. (from Lumigan Label)
Additional Information
Please visit Allergan for additional information on their products.
If you are interested in learning more about glaucoma, please visit the National Institutes of Health, National Eye Institute.
The FDA drug information shown here is licensed from Thomson CenterWatch. The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.
