Neurontin (gabapentin)
Company: Pfizer
Approval Status: Approved May 2002
Treatment for: Post-herpetic neuralgia (PHN)
Areas: Neurology
Possible similar drugs: Neurontin; Neurontin
| General Information | Clinical Results | Side Effects | Mechanism of Action | Additional Information |
General Information
PHN is a syndrome of often intractable pain that persists after the resolution of herpes zoster, a condition commonly known as shingles. This intense pain is described as burning, deep aching, tearing and electric shock-like. Approximately 10 to 15 percent of all patients with herpes zoster develop PHN, which may persist for a number of years.
Clinical Results
The approval of Neurontin was supported by a multi-center trial involving 229 subjects with PHN. Results showed that subjects suffering from PHN experienced a statistically significant reduction in average daily pain after treatment with Neurontin. Almost twice as many subjects treated with Neurontin (16 percent) were pain-free versus those treated with placebo (8.8 percent) at the end of the trial. The study also showed that those receiving Neurontin experienced improvement in sleep and overall quality of life.Side Effects
Adverse events associated with the use of Neurontin may include (but are not limited to) the following:- Dizziness
- Somnolence
- Peripheral edema
Mechanism of Action
The mechanism of action exerted by Neurontin (gabapentin) is unknown. Gabapentin is structurally related to the neurotransmitter GABA, but it does not interact with GABA receptors, is not converted metabolically into GABA or a GABA agonist and is not an inhibitor of GABA uptake or degradation. (Neurontin prescribing information)Additional Information
For additional information on Neurontin, please visit Pfizer.The FDA drug information shown here is licensed from Thomson CenterWatch. The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.



