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Company: Roche
Approval Status: Approved June 1997
Treatment for: hypertension and chronic stable angina pectoris
Areas: Cardiovascular / Cardiology; Diabetes / Endocrinology; Neurology & Nervous System

| General Information | Side Effects | Mechanism of Action |

General Information

Posicor (mibefradil), a calcium channel blocker, will be available in 50 mg and 100 mg tablets for treatment of chronic stable angina pectoris and hypertension. Posicor is approved for use by itself or in combination with other antihypertensive or anti-anginal agents.

Side Effects

Posicor is contraindicated for use with astemizole, terfenadine and cisapride because it is metabolized by the cytochrome P450 2D6 isoenzyme. It can be life-threatening when used in conjunction with agents metabolized by P450.

Mechanism of Action

Mibefradil, a subtype calcium channel blocker, blocks both low and high voltage calcium channels with greater selectivity for low voltage or Type T channels. While decreasing blood pressure, Posicor doesn’t lessen heart contractions, unlike beta blockers.

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Posicor Drug Information

The Posicor drug information shown above is licensed from Thomson CenterWatch. The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.

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