Approved September 2006
Verdeso (desonide) Foam is a petrolatum-based emulsion aerosol foam containing the active ingredient desonide, a low-potency topical corticosteroid. Desonide is a white powder or crystal that is practically insoluble in water, sparingly soluble in ethanol and in acetone, and soluble in chloroform.
Verdeso is specifically indicated for the treatment of mild to moderate atopic dermatitis in patients 3 months of age and older.
Verdeso is supplied in 100 g aluminum cans. The recommended initial dose of the drug is a thin layer applied to the affected area(s) twice daily. The smallest amount of foam necessary to adequately cover the affected area(s) with a thin layer should be used.
FDA approval of Verdeso was based on results of one clinical trial. This double-blind, randomized trial enrolled 581 subjects, ages 3 months to 17 years old, with mild to moderate atopic dermatitis, who received Verdeso Foam applied twice daily for 4 weeks. Of the subjects on the Verdeso treatment 39% achieved success, defined as an Investigator's Static Global Assessment (ISGA) score of clear or almost clear, a minimum improvement in the 5 point ISGA score of 2 grades from baseline to week 4, and a score of absent or minimal for both erythema and induration/papulation at week 4. Only 9% of the subjects on placebo achieved success.
Ongoing Study Commitments
Adverse events associated with the use of Verdeso may include, but are not limited to , the following:
In addition, in a clinical study Verdeso was shown to cause adrenal suppression in 4% of the pediatric subjects after 4 weeks of use. Systemic absorption of topical corticosteroids has produced reversible HPA axis suppression, manifestations of Cushing’s syndrome, hyperglycemia, and glucosuria in some patients. Verdeso Foam is contraindicated in subjects who are hypersensitive to desonide or to any ingredient in this preparation. Treatment should not exceed four consecutive weeks.
Verdeso Foam is a topical corticosteroid which are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. These proteins are believed to control the biosynthesis of potent mediators of inflammation, such as prostaglandins and leukotrienes, by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.
For additional information regarding Verdeso or atopic dermatitis, please vist the Connetics web page.
The Verdeso (desonide) drug information shown above is licensed from Thomson CenterWatch. The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.