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Zoloft (sertraline HCl)

Company: Pfizer
Approval Status: Approved July 1997
Treatment for: panic disorder
Areas: Psychiatry / Psychiatric
Possible similar drugs: Zoloft; Zoloft

| General Information | Clinical Results | Side Effects | Additional Information |

General Information

The U.S. Food and Drug Administration cleared Pfizer to market Zoloft (sertraline HCl) for the treatment of panic disorder. Zoloft also received new labeling for maintaining antidepressant efficacy for up to 52 weeks in the treatment of depression. Zoloft was introduced for the treatment of depression in 1992 and, in 1996, for obsessive-compulsive disorder. The new clearance specifies that Zoloft may be marketed for the treatment of panic disorder, with or without agoraphobia.

Clinical Results

In clinical trials with adult patients, Zoloft demonstrated significant reduction in frequency of panic attacks without regard to age, gender or race. Patients suffering from panic disorder experience recurrent, unexpected panic attacks. The more common symptoms include heart palpitations, sensations of shortness of breath, dizziness and fear of losing control or going crazy. Panic attacks, or the fear of them, can also result in worry, concern or even dramatic behavioral and lifestyle changes.

Side Effects

The most common side effects were diarrhea, ejaculation failure, tremor, constipation, agitation, increased sweating, anorexia, and decreased libido.

Additional Information

Panic disorders is a disease which will afflict an estimated four to eight million American adults at some point in their lives. Agoraphobia is an incapacitating anxiety that can restrict people to their homes. Panic disorder is two to three times more prevalent among women. Onset occurs between late adolescence and the mid-30s.

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Zoloft Drug Information

The Zoloft drug information shown above is licensed from Thomson CenterWatch. The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.

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