Definition: 'Howell-Jolly Bodies'
Howell-Jolly bodiesType: Term
Pronunciation: how′ĕl zhō-lē′
1. spheric or ovoid eccentrically located granules, approximately 1 mcm in diameter, occasionally observed in the stroma of circulating erythrocytes, especially in stained preparations (as compared with wet unstained films); probably represent nuclear remnants, staining with dyes that are rather specific for chromatin; the significance of the bodies is not exactly known; they occur most frequently after splenectomy or in megaloblastic or severe hemolytic anemia.
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