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Definition: 'Immune Complex Disease'

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immune complex disease

Type: Term

Definitions:
1. an immunologic category of diseases evoked by the deposition of antigen-antibody in the microvasculature. Complement is frequently involved and the breakdown products of complement attract polymorphonuclear leukocytes to the site of deposition. Damage to tissue is frequently caused by “frustrated” phagocytosis by polymorphonuclear cells. Vasculitis or nephritis is common. Other clinical manifestations include fever, arthralgias, and cutaneous eruptions. Arthus phenomenon and serum sickness are classic examples, but many other disorders, including most of the connective tissue diseases, may belong in this immunologic category. Immune complex diseases can also occur during a variety of diseases of known etiology, such as subacute bacterial endocarditis.

Synonyms: immune complex disorder, type III hypersensitivity reaction

The definition information for immune complex disease is provided by Stedman's. You can search our medical dictionary here.

Stedman's, part of Lippincott Williams & Wilkins, provides a comprehensive line of health-science publications for healthcare professionals and medical students.

Medical Dictionary Copyright © 2006 Lippincott Williams & Wilkins. All rights reserved.







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