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Definition: 'Complement Fixation'

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complement fixation

Type: Term

Definitions:
1. antigen-antibody interactions cause a conformational shift in immunoglobulin structure promoting binding of C1 and subsequent activation of the complement cascade, complement fixation.
2. an immunoassay using reference antibodies with complement fixation and lysis of red blood cells as an indicator of detectable antigen. The degree of hemolysis affects the optic density of the sample, which can be measured and compared with a standard reference concentration curve.

Synonyms: CF test, complement binding assay

The definition information for complement fixation is provided by Stedman's. You can search our medical dictionary here.

Stedman's, part of Lippincott Williams & Wilkins, provides a comprehensive line of health-science publications for healthcare professionals and medical students.

Medical Dictionary Copyright © 2006 Lippincott Williams & Wilkins. All rights reserved.







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