MediLexicon Logo
MediLexicon Logo
Abbreviations        Abbrev Definitions        Dictionary        ICD Codes        Equipment        Hospitals        Drugs        More..
  
Bookmark and Share

Definition: 'Sickle Cell Anemia'

Medical term:     fuzzy search?

Dictionary by letter (or # for non-alphabetical entries):
| # | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z |

sickle cell anemia

Type: Term

Definitions:
1. an autosomal recessive anemia characterized by crescent- or sickle-shaped erythrocytes and accelerated hemolysis, due to substitution of a single amino acid (valine for glutamic acid) in the sixth position of the β-chain of hemoglobin, the gene of which is on chromosome 11; affected homozygotes have 85–95% hemoglobin (Hb) S and severe anemia, whereas heterozygotes (said to have sickle cell trait) have 40–45% Hb S, the rest being normal Hb A; low oxygen tension causes polymerization of the abnormal β-chains, thus distorting the shape of the red blood cells to the sickle form. Homozygotes develop “crisis” episodes of severe pain due to microvascular occlusions, bone infarcts, leg ulcers, and atrophy of the spleen associated with increased susceptibility to bacterial infections, especially streptococcal pneumonia. Occurs most commonly in people of African descent.

Synonyms: drepanocytic anemia, sickle cell disease

The definition information for sickle cell anemia is provided by Stedman's. You can search our medical dictionary here.

Stedman's, part of Lippincott Williams & Wilkins, provides a comprehensive line of health-science publications for healthcare professionals and medical students.

Medical Dictionary Copyright © 2006 Lippincott Williams & Wilkins. All rights reserved.







MediLexicon International Ltd Logo

Privacy Policy   |    Disclaimer   |    Contact / Feedback

MediLexicon International Ltd
Bexhill-on-Sea, UK
MediLexicon International Ltd © 2004-2014 All rights reserved.