Definition: 'Janus Kinase'
Janus kinase (JAK)
Type: Term
Definitions:
1. a member of a particular family (JAK) of tyrosine kinases involved in cytokine receptor signaling. Mutations in JAK3 on chromosome 19p cause autosomal recessive severe combined immunodeficiency [MIM*600173]. JAK1 and JAK2 are mapped to the short arms of chromosomes 1 and 9, respectively.
The information shown above for Janus kinase is provided by Stedman's.
* Stedman's, part of Lippincott Williams & Wilkins, provide a comprehensive line of health-science publications for healthcare professionals and medical students.
Stedman's Medical Dictionary. Copyright © 2006 Lippincott Williams & Wilkins. All rights reserved.
