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Definition: 'Lipoic Acid'

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lipoic acid

Type: Term

Pronunciation: li-pō′ik as′id

Definitions:
1. A bacterial growth factor present in yeast and liver extracts; may be useful in the treatment of mushroom poisoning. Functions as the amide (lipoamide) cofactor in the disulfide (—S—S—) form in the transfer of “active aldehyde” (acetyl), the two-carbon fragment resulting from decarboxylation of pyruvate from α-hydroxyethylthiamin pyrophosphate to acetyl-CoA, itself being reduced to the dithiol form (dihydrolipoic acid) in the process. Lipoic acid is also an essential component of other α-keto acid dehydrogenase complexes.

Synonyms: acetate replacement factor, ovoprotogen, protogen, protogen A, pyruvate oxidation factor, thioctic acid



The information shown above for lipoic acid is provided by Stedman's.

* Stedman's, part of Lippincott Williams & Wilkins, provide a comprehensive line of health-science publications for healthcare professionals and medical students.

Stedman's Medical Dictionary. Copyright © 2006 Lippincott Williams & Wilkins. All rights reserved.





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