New Gene Identified With A Key Role In Obesity And Diabetes

news headlines

email to a friend

printer friendly

New Gene Identified With A Key Role In Obesity And Diabetes

Main Category: Obesity / Weight Loss / Fitness
Also Included In: Diabetes | Genetics
Article Date: 12 Jan 2013

Scientists observed that blocking the expression of the gene TRIP-Br2 in mice protects them against obesity and insulin resistance. The study shows that the gene modulates fat storage by regulating energy expenditure and lipolysis, the process which transforms fat into lipids for the body's energy consumption. If the gene expression is blocked, the mice increase their lipolysis and their energy expenditure, thus reducing their obesity.

Obesity is the result of an alteration in the processes that regulate food absorption and energy production. This alteration tips the balance towards excessive storage of fat. According to the researchers, understanding the regulation of the factors that control the storage, mobilisation and use of excess energy in fat cells (the adipocytes) can lead to the development of therapies for obesity and its related illnesses, such as type 2 diabetes.

In the words of Cristina Mallol, a researcher at the Universitat Autònoma de Barcelona and co-author of the study: "The protection of mice with no expression of the gene TRIP-Br2, and its selective elevation in the visceral fat of humans point the way to a future gene therapy to counteract obesity, insulin resistance and excess lipids in the blood".

Original article posted on Medical News Today.
Articles not to be reproduced without permission of Medical News Today

Medical News Today publishes the latest health news and health videos for consumers and health professionals. It has a searchable archive of over 100,000 health news articles.

< back to medical news

For any corrections of factual information, or to contact the editors please use our feedback form.

Send your press releases to