Certain Markers For Down's Syndrome More SignificantMain Category: Pregnancy / Obstetrics
Also Included In: Pediatrics / Children's Health | Genetics
Article Date: 31 Jan 2013
Certain second trimester markers for Down's syndrome that are identified in an ultrasound are more significant than others.
The finding came from new research published in the journal Ultrasound in Obstetrics & Gynecology. The results of this investigation will help modify pregnant women's risks for having a baby with the chromosomal disorder.
Every pregnant woman is asked whether she would like screening for Down's syndrome, who begin with a background risk based on how old they are.
There are specific characteristics identified during an ultrasound exam in the second trimester of a woman's pregnancy that are possible indicators for Down's syndrome.
The potential markers include:
They looked at all research published between 1995 and 2012 that demonstrated results on markers for Down's syndrome detected during the second trimester of pregnancies.
After finding 48 reports, they determined that the most single markers have only a little impact on altering the likelihood for Down's syndrome.
The authors explained:
"This finding could have important clinical implications because currently in the United States, when a marker such as a short arm or thigh bone is detected, women are told that they are at high risk of having a child with Down's syndrome."
The researchers, however, did find some markers that indicate increased risks.
The risk increases three to four times when the following are detected:
The research also demonstrated that the risk of having a child with Down's syndrome is reduced seven times if a comprehensive ultrasound exam during the second trimester shows that all major markers are nonexistent.
The results demonstrate that the relative significance of ultrasound markers is very different to what scientists have believed in the past.
The findings from this report will be included in obstetric ultrasound scan software that alters women's risks for giving birth to a baby affected by Down's syndrome, Professor Nicolaides concluded.
Written by Sarah Glynn
Copyright: MediLexicon International Ltd
Original article posted on Medical News Today.
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