 A Cellular Adhesion Protein Protects Against InflammationMain Category: StrokeArticle Date: 05 Feb 2013 Cellular inflammation is mediated by a group of proteins known as the inflammasome. In this issue of the Journal of Clinical Investigation, Ziad Mallat and colleagues at Addenbrooke's Hospital in Cambridge, England, identified a protein, MFGE8, that blocks inflammasome activity. Using a mouse model of stroke, Mallat and colleagues determined that expression of MFGE8 inhibited the production of pro-inflammatory products and limited the area of injury after stroke. These results identify MFGE8 as an important regulator of inflammation that could potentially serve as a useful therapeutic target in inflammatory disease. TITLE: MFGE8 inhibits inflammasome-induced IL-1β production and limits post-ischemic cerebral injury View this article at: http://www.jci.org/articles/view/65167?key=9c368b2173b91a4a0e01 Original article posted on Medical News Today. Articles not to be reproduced without permission of Medical News Today Medical News Today publishes the latest health news and health videos for consumers and health professionals. It has a searchable archive of over 100,000 health news articles. < back to medical news
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