High Calcium Supplement Intake Raises Male Cardiovascular Disease Death RiskMain Category: Bones / Orthopedics
Also Included In: Cardiovascular / Cardiology | Stroke
Article Date: 05 Feb 2013
Men who have a high intake of calcium supplements appear to have a greater risk of CVD (cardiovascular disease) death, researchers from the National Cancer Institute, Bethesda, Md., reported in JAMA Internal Medicine. The authors noted that women do not appear to be affected in the same way.
Elderly Americans are taking calcium supplements in progressively higher numbers, the authors explained as background information. They do so because of the health benefits for their bones. However, apart from the benefits in the prevention and treatment of osteoporosis, experts are not sure what non-skeletal health effects they might have. In fact, the subject has become "increasingly contentious".
Qian Xiao, Ph.D. and team set out to determine whether the consumption of dietary and supplemental calcium might be linked to mortality from total cardiovascular, heart, and cerebrovascular diseases. There were a total of 388,229 participants in the study, men and women aged from 50 to 71 years from the NIH-AARP Diet and Health Study, across six states and two major cities from 1995 to the end of 1996.
They found that supplemental, but not dietary calcium intake, was linked to greater CVD mortality in men but not in women.
The participants were followed-up for an average of 12 years. During that period 3,874 CVD deaths in women and 7,904 in men were identified. 51% of the men and 70% of the women regularly took calcium supplements.
The men on over 1,000 mg/day calcium supplementation had a 20% greater risk of total CVD death (including 19% higher heart disease and 14% higher cerebrovascular disease risk of death).
Taking calcium supplements was not linked to CVD death, heart disease or cerebrovascular disease death among the women.
The researchers concluded:
"Whether there is a sex difference in the cardiovascular effect of calcium supplement warrants further investigation. Given the extensive use of calcium supplement in the population, it is of great importance to assess the effect of supplemental calcium use beyond bone health," the authors conclude.
Is Calcium Supplementation Harmful to Cardiovascular Disease? CommentarySusanna C. Larsson, Ph.D., of the Karolinska Institutet, Stockholm, Sweden, in a Commentary in the same journal, wrote:
"More large studies are needed to further assess the potential health risks or benefits of calcium supplement use on CVD morbidity and mortality.
Many Studies Show Calcium Supplements May Raise Heart Attack RiskSome studies over the years have pointed to a higher risk of heart and/or cardiovascular diseases associated with taking calcium supplements. Two studies are listed below:
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