Global Management Of Anemia In Children On DialysisMain Category: Blood / Hematology
Also Included In: Urology / Nephrology | Pediatrics / Children's Health
Article Date: 10 Mar 2013
Children on dialysis who have anemia and who require high doses of drugs to treat it have an increased risk of dying prematurely, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN). The findings provide new insights that may help improve the health of children with kidney failure.
Many patients on dialysis develop anemia, which can be treated with erythropoesis stimulating agents (ESAs) to boost hemoglobin, the component of blood that transports oxygen throughout the body. Using these medications presents considerable challenges, though: patients respond differently to the drugs, and using them too aggressively increases the risk of heart-related problems and premature death. Proper anemia control in children on dialysis is even less clear than in adults.
Franz Schaefer, MD (University of Heidelberg) and his colleagues conducted a five-year study to examine anemia control in children undergoing chronic peritoneal dialysis, hoping to identify factors that interfere with anemia management and to assess whether there are upper and lower hemoglobin levels that may compromise patient survival. The study included nearly 1,400 children and adolescents from 81 pediatric dialysis centers in 30 countries around the globe.
"Given the low incidence of pediatric end-stage renal disease in children - only 1% to 2% of all dialysis patients are children - this study is remarkable as it overcame the patient size limitations that notoriously hamper clinical research in this area," said Dr. Schaefer.
Among the major findings:
Original article posted on Medical News Today.
Articles not to be reproduced without permission of Medical News Today