In High-Risk Prostate Cancer, Zoledronic Acid Not Found To Prevent Bone Metastases

news headlines

email to a friend

printer friendly

In High-Risk Prostate Cancer, Zoledronic Acid Not Found To Prevent Bone Metastases

Main Category: Prostate / Prostate Cancer

Article Date: 21 Mar 2013

The initial study results of the Zometa European Study (ZEUS) showed no difference in the incidence of bone metastases between the Zometa group and control arm, said Prof. Manfred Wirth during the closing and fourth plenary session of the 28th Annual EAU Congress.

"There is no difference in the incidence of bone metastases and there is no difference in survival," said Wirth in his brief presentation on whether Zometa can prevent bone metastases in high risk, metastatic prostate cancer patients. The ZEUS study, supported by the EAU Research Foundation, looked into the efficacy and safety results after a median follow-up of 50 months. Zoledronic acid (Zometa®) is a third-generation nitrogen-containing Bisphosphonate, approved in Europe and the US for the treatment of bone metastases in a broad range of tumours.

Zoledronic acid was expected to show its potential in preventing hormone therapy induced bone loss. Patients were randomised between standard treatment plus Zometa® 4 mg infusions every three months for a total of 48 months. "There were regional variations in the numbers of patients who developed bone metastases," added Wirth as he noted that locally treated patients developed less bone metastases.

Original article posted on Medical News Today.
Articles not to be reproduced without permission of Medical News Today

Medical News Today publishes the latest health news and health videos for consumers and health professionals. It has a searchable archive of over 100,000 health news articles.

< back to medical news

For any corrections of factual information, or to contact the editors please use our feedback form.

Send your press releases to