xanthurenic acid[zan′thū-rēn′ik as′id]


1. This compound a metabolic product resulting from indoleamine 2,3-dioxygenase (IDO) breakdown of tryptophan, may accumulate in human lens cells and play a role in senile-onset lens pathology, leading to lens cell apoptosis. Excreted in the urine of pyridoxine-deficient animals after the ingestion of tryptophan, and of rats fed almost exclusively with fibrin, the sulfur-yellow crystals form a red compound with Millon reagent, or an intensely green one with ferrous sulfate.

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