1. A disease of many tropic and subtropic regions that can occur epidemically; caused by dengue virus, a member of the family Flaviviridae. There are four antigenic types, and they are transmitted by a mosquito of the genus Aedes (usually A. aegypti, but frequently A. albopictus). Four grades of severity are recognized: grade I, fever and constitutional symptoms; grade II, grade I with spontaneous bleeding (of skin, gums, or gastrointestinal tract); grade III, grade II with agitation and circulatory failure; grade IV, profound shock.
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