1. A change, for the better or for the worse, in the course of a disease.
2. A general move toward a given point.
3. The measurement or estimation of any quantity or quality in scientific or laboratory investigation.
4. Discernment of a state or category (in diagnosis).
5. A process, both necessary and sufficient, whereby an effect is caused.
Stedman’s Medical Dictionary © Wolters Kluwer Health. All rights reserved.