H-Y antigen


1. an antigen factor, dependent on the Y chromosome, responsible for the differentiation of the human embryo into the male phenotype by inducing the initially bipotential embryonic gonad to develop into a testis; in the absence of this antigen, the indifferent gonad develops into an ovary. There are at least two loci involved, an autosomal gene that generates the antigen [MIM*143170] and one that makes the receptor [MIM*143150].

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